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Obesity-related cancer risk may grow with both good and bad kinds of obesity

According to recent research, both metabolically healthy and unhealthy 'forms' of obesity are associated with an elevated risk of various malignancies connected to obesity, with the relationship being stronger in metabolically unhealthy obesity. The research were published in the National Cancer Institute Journal. The investigation was carried out by Dr. Ming Sun of Lund University in Malmo, Sweden, and associates.
There aren't many research on the link between healthy obesity and cancer or obesity with metabolic problems.
Researchers looked studied the association between metabolic health status and body mass index (BMI, normal weight/overweight/obesity) regarding obesity-related cancer risk (n=23,630) in 797,193 Europeans.
To distinguish between metabolically healthy and unhealthy settings, statistical modeling was used to look for any correlations between a metabolic score that took into account blood pressure, plasma glucose, and triglycerides (blood fats).
As a result, the participants were divided into six groups: metabolically unhealthy obesity (6.8% of participants), metabolically healthy obesity (3.4%), metabolically unhealthy overweight (15.4%), metabolically healthy overweight (19.8%), metabolically unhealthy normal weight (12.5%), and metabolically healthy normal weight (42.0%).
The highest risk estimates for endometrial, liver, and renal cell cancer (2.5 to 3.0 times increased risk) were found when compared to metabolically healthy normal weight. Metabolically unhealthy obesity was also linked to an increased relative risk of any obesity-related cancer, including colon, rectal, pancreatic, endometrial, liver, gallbladder, and renal cell cancer.
Metabolically unhealthy obese women had a 21% higher risk of colon cancer, a 3-times higher risk of endometrial cancer, and a 2.5-times higher risk of kidney cancer than metabolically healthy obese women of normal weight. Obese women who were metabolically healthy had a 2.4-fold higher risk of endometrial cancer and an 80% higher risk of kidney cancer, but the link to colon cancer was no longer statistically significant.
Metabolically unsound males with obesity had a 2.6-fold greater risk of kidney cancer in men compared to metabolically healthy men of normal weight, an 85% increased risk of colon cancer, and a 32% increased risk of pancreatic and rectal cancer. Obesity raised the risk of colon cancer by 42% and kidney cancer by 67% in metabolically healthy men, but it no longer had a statistically significant effect on the risk of rectal cancer or pancreatic cancer. The blood cancer multiple myeloma was shown to have a roughly 50% higher risk in both metabolically healthy and unhealthy men who were overweight (not obese), but not in metabolically healthy or unhealthy men who were obese.
According to the authors, the findings imply that, among males alone, obesity and metabolic issues together enhance the risk of these obesity-related malignancies more than would be predicted from the sum of each risk factor alone. They write: “This has important public health implications, suggesting that addressing the co-existence of metabolic issues and obesity, in particular for obesity-related cancers among men, could potentially prevent a significant number of cancer cases.”
“This study highlights the importance of the type of metabolic obesity phenotype when assessing obesity-related cancer risk,” the scientists write in their conclusion. Overall, having a dysfunctional metabolism raised the likelihood of developing cancer associated with obesity, indicating that both obesity and metabolic disorders might be good preventative strategies.

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